New toys for nuclear cardiologists.

Gordon Liljestrand is credited with establishing modern nuclear cardiology as a noninvasive imaging modality in 1939.1 Table summarizes major technological advancements in myocardial perfusion imaging over the past 70 years that have led to more accurate assessment of coronary artery disease (CAD). Most of these technical advances have involved radioisotopes and computer software. Camera hardware has undergone relatively little change since the introduction of the gamma camera, also commonly referred to as the scintillation camera, by Hal Anger in 1958.2 The gamma camera has performed admirably as the workhorse for myocardial perfusion imaging over the years but has several limitations. Sensitivity and resolution are modest. Imaging is inefficient as the heart occupies only a small portion of the field of view. Imaging places several demands on the patient, requiring relatively long imaging times (8 to 12 minutes) while lying motionless on a narrow, hard table with one or both arms fully abducted to minimize the distance between the patient’s chest and the rotating detectors. The relatively long imaging times require administration of fairly high doses of radioisotopes with attendant higher radiation exposure, an issue of increasing medical and societal concern.3